Mori, M. A. et al.
Geekiyanage, H. et al.
Thomou, T. et al.
Adipose-derived circulating miRNAs regulate gene expression in other tissues.
Becher, T. et al.
Mori, M. A. et al. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 30, 656–673 (2019). This review summarizes known roles of miRNAs in cell–cell communication.
Geekiyanage, H. et al. Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides. Proc. Natl Acad. Sci. USA 117, 24213–24223 (2020). This study shows that circulating miRNAs are associated with sEVs and are bound to AGO2 in humans.
Thomou, T. et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature 542, 450–455 (2017). This study demonstrated that adipose tissue (and especially BAT) is a major source of circulating miRNAs.
Becher, T. et al. Brown adipose tissue is associated with cardiometabolic health. Nat. Med. 27, 58–65 (2021). This study showed the importance of detectable BAT in cardiometabolic disease in humans.
