RESEARCH HIGHLIGHT18 June 2026 New antibiotic targets novel ribosomal site By Sarah Crunkhorn Sarah Crunkhorn View author publications PubMed Google ScholarMicrobial natural products, particularly those derived from actinomycetes bacteria, have served as a rich source of antibiotics for many decades.
However, interest in actinomycetes as sources of new antimicrobials has declined, in part due to the repeated rediscovery of known chemical scaffolds.
Writing in Nature, Kaur et al.
now report the identification of a new antibiotic produced by an actinomycetes strain, that targets a novel site on the bacterial ribosome.
The antibiotic was effective against multidrug-resistant Enterobacteriaceae pathogens in vitro and in vivo.
RESEARCH HIGHLIGHT
18 June 2026 New antibiotic targets novel ribosomal site By Sarah Crunkhorn Sarah Crunkhorn View author publications PubMed Google Scholar
Microbial natural products, particularly those derived from actinomycetes bacteria, have served as a rich source of antibiotics for many decades. However, interest in actinomycetes as sources of new antimicrobials has declined, in part due to the repeated rediscovery of known chemical scaffolds. Writing in Nature, Kaur et al. now report the identification of a new antibiotic produced by an actinomycetes strain, that targets a novel site on the bacterial ribosome. The antibiotic was effective against multidrug-resistant Enterobacteriaceae pathogens in vitro and in vivo.
doi: https://doi.org/10.1038/d41573-026-00105-6
