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Health / Tue, 03 Nov 2026 The Hindu

How smoking sets the stage for lung cancer | Explained

Oncologists have long wrestled with a conundrum. Healthy human tissue often carries mutations that can drive cancer, but the tissue itself does not develop tumours. Clearly, a genetic spark alone is not enough. At the same time, chronic inflammation from smoking profoundly damages lung tissue long before any definitive cancer-causing mutations even take root. How then does smoking increase the risk of lung cancer?

Oncologists have long wrestled with a conundrum. Healthy human tissue often carries mutations that can drive cancer, but the tissue itself does not develop tumours. Clearly, a genetic spark alone is not enough. At the same time, chronic inflammation from smoking profoundly damages lung tissue long before any definitive cancer-causing mutations even take root.

How then does smoking increase the risk of lung cancer?

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